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Ketamine drug (brand name: Ketalar) is a dissociative injected anesthetic (blocks sensory perception) that has been available by prescription in the US for human and veterinary use since the 1970s. Esketamine (Spravato), the S-enantiomer of racemic ketamine, was approved in 2019 for treatment-resistant depression and is approved for use in depressed patients with acute suicidal thoughts or behavior. Ketaset is the brand name of a surgical anesthesia used by veterinarians, buy ketamine, ketamine effects, what is ketamine, ketamine drug, ketamine drug,
Dissociative drugs can lead to distortion of images, colors, sounds, the self and the environment. Ketamine is available in a clear liquid or off-white powder form for intravenous injection or as a nasal spray. Examples of other dissociative drugs include phencyclidine (PCP) and dextromethorphan (DXM).
In the US, ketamine is classified as a Schedule III drug under the DEA Controlled Substances Act; however, it is not classified as an opioid (narcotic) or barbiturate. what is ketamine,
- Ketamine drugs can provide pain relief and short-term memory loss (for example, memory loss from a medical procedure).
- In surgery it is used as an induction and maintenance agent for sedation and for general anesthesia.
- It has also been used for pain management in burn therapy, battlefield injuries, and in children who cannot use other anesthetics due to side effects or allergies.
- By blocking at the site of N-methyl-D-aspartate (NMDA), ketamine has a rapid action in controlling symptoms of depression and acute suicidal ideation.
- At normal doses it is often preferred as an anesthetic in patients at risk of bronchospasm and respiratory depression. buy ketamine,
Ketamine drug is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and blocks HCN1 receptors. However, at higher doses it can also bind to the opioid mu and sigma receptors. It disrupts the neurotransmitter (brain chemical) glutamate. Glutamate is involved in learning, memory, emotion and pain recognition. It may exhibit sympathomimetic activity that can lead to rapid heart rate and increased blood pressure.
It is related to phencyclidine (PCP), but has less than 10% of the potency of pure PCP.
This drug is a fat-soluble compound, has an initial rapid distribution and a large volume of distribution, with a half-life of 10 to 15 minutes. Secondly, the drug distributes into peripheral tissues with a slower elimination half-life of up to 3 hours, undergoes hepatic metabolism and is excreted in the urine. ketamine effects, ketamine drug,
- An injection provides a rapid response, with effects occurring in seconds to minutes.
- “Snorting” produces effects in about 5 to 15 minutes (this is the most common method of abuse).
- Oral consumption requires between 5 and 30 minutes.
The effects of abuse typically last 1 to 2 hours, but the user’s judgment, senses, and coordination can be impaired for up to 24 hours or more. Sensations the user can seek include floating, stimulation, and visual effects.
High doses can dangerously impair breathing, lead to muscle spasms or weakness, dizziness, balance problems, impaired vision, slurred speech, nausea and vomiting, and severe confusion.
Binge use, in which the user indulges in the drug in excessive amounts over a short period of time, has also been reported.
75 to 125 mg intramuscular (IM) or subcutaneous injection
60 to 250 mg insufflation (intranasal or “sniffing”)
50 to 100 mg intravenous (IV)
200 to 300 mg orally (by mouth)
Abuse of large doses can also lead to powerful visual hallucinations that are enhanced by environmental stimuli. Coma and profound unconsciousness may occur. When higher doses of ketamine are abused, or during waking, it is reported to cause vivid dreams and an “out of body” hallucinogenic experience, “K-hole” or “near-death”, often reported as terrifying (similar to a bad LSD trip).
In smaller doses, such as those typically used recreationally, ketamine can lead to various effects, such as:
- feelings of calm and relaxation, relief from pain
- depressive mental state
- detached feeling from body
- slurred speech
- reduced reflexes
- hallucinations lasting 30 to 60 minutes
- nystagmus (repetitive, uncontrolled movements of the eyes). what is ketamine, ketamine drug,
The most common side effects of ketamine in medical use are nausea, vomiting, dizziness, diplopia (double vision), drowsiness, dysphoria (discomfort, restlessness), and confusion. There is also the risk of HIV, hepatitis and other infectious diseases from shared needles. buy ketamine,
Ketamine use can be fatal in people who are alcoholics or acutely intoxicated from alcohol. There have been reports in animals of an increased risk of toxicity when ketamine is combined with caffeine. Theoretically, this could be a concern in people who have consumed energy drinks, often done in nightclubs where ketamine may be abused.
- In the event of a ketamine overdose, emergency services such as 911 should be contacted immediately.
- There is no antidote for this drug. Overdose situations are treated with symptomatic and supportive care in the hospital setting. In the emergency department, side effects usually resolve within 1 to 3 hours. ketamine effects,
- Benzodiazepines such as lorazepam can be used as needed for seizures, agitation, or muscle stiffness.
- Breathing support is rarely necessary, but assisted ventilation or supplemental oxygen may be necessary. Respiratory depression may be more likely when combined with sedative medications.
- Those who abuse this drug should be referred for drug counseling. what is ketamine, ketamine drug, buy ketamine , oxycodone 10 mg , buy Benzedrine , snort MDMA , buy cocaine online 1g , , . . . . . . . . . . . . . . . .
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